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However, besides the gt2a isolate JFH1 15 , all wildtype (WT) isolates needed to acquire cell culture adaptive mutations to replicate in hepatoma cells commonly used in cell culture 16

Similar results were obtained using proteinase K digestion of proIGF-1Ea (Supplementary Fig

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Subgroup analyses indicated that older patients and those with heart failure may experience greater benefits

2, Supplemental Material 1, Figure S1) was registered at www.clinicaltrials.gov under number NCT04946526 and approved by the Institutional Review Board of Appalachian State University (protocol number # 21-02216) where all interventions were conducted and samples were collected