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Administered as a once-weekly subcutaneous injection, tirzepatide is typically initiated at 2.5 mg and increased by 2.5 mg every 4 weeks to a target dose of 5-15 mg as tolerated

The 2.5 mg starting dose is explicitly a tolerability dose in trials it was not intended to drive weight loss on its own, but to let the gut acclimate before therapeutic doses begin

Industry experts say semaglutide drugs will become cheaper and more accessible for patients with diabetes and obesity