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Metformin reduces aging-related leaky gut and improves cognitive function by beneficially modulating gut microbiome/goblet cell/mucin Axis

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Vitamin B12 (also known as cobalamin) is a water-soluble vitamin that plays an important role in metabolism, red blood cell formation, and nerve function

Accordingly, several stress-reducing therapies or pharmacological inhibition of adrenergic signalling were demonstrated to decrease the incidence and lower mortality of patients with diverse types of tumours including prostate cancer [209]

Of those compounds, berberine exhibits the highest binding energy to the binding pocket of core target proteins

Nov 7 2025;doi:10.1056/NEJMoa2513032