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A prooxidant effect of ascorbate dependent on the time at which it was administered to rats has been demonstrated (Kang et al., Another study reported an increase in 8-oxoadenine levels (DNA oxidative damage marker) and, paradoxically, a decrease in 8-oxoguanosine levels from basal measurements when supplementing 30 healthy volunteers with 500 mg/day of vitamin C for 6 weeks, compared to the results observed with the placebo group (Podmore et al., 1998)

The human body is a complex, interconnected system

Whats the actual risk

(6) This form may be particularly beneficial for those seeking quicker effects from their supplementation

May contain the wrong ingredients May include harmful contaminants May have incorrect dosing or concentrations Some products may be unsterilized These are not minor risks

Endothelial NO synthesis using fluorescent dyes such as DAF-2 DA and DAF-FM DA for in situ NO detection (531)