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Fumarate, also an intermediate metabolite of the TCA cycle, conventionally links arginine metabolism to glucose-generated energy metabolism

Metformin reduces glucose production in the liver, while semaglutide (Ozempic) slows digestion and increases insulin releasetwo separate mechanisms that often work synergistically

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PMID 33567185 DOI Jastreboff AM, Aronne LJ, Ahmad NN, et al