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It is usually not painful but can be bothersome

Effect on Weight Reduction and Long-Term Maintenance Four 56-week multicenter, double-blind, placebo-controlled obesity trials (CONTRAVE Obesity Research, or COR-I, COR-II, COR-BMOD, and COR-Diabetes) were conducted to evaluate the effect of CONTRAVE on weight reduction in conjunction with lifestyle modification in 4,536 patients randomized to CONTRAVE or placebo

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It argues this measured approach reduces the incidence of severe nausea and gastrointestinal distress compared with faster schedules, and stresses that the pacing is a provider decision

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