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Epidemiologic studies report associations between circulating osteocalcin levels and markers of metabolic health, including glucose tolerance and insulin sensitivity, but effect sizes vary and causality remains uncertain ( Rather than undermining osteocalcins relevance, these challenges highlight the need for standardized assays, context-aware study designs, and pharmacologic tools that directly modulate osteocalcin signaling

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It has also been used in humans to protect them from kidney damage from chemotherapy drugs

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