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The AWARD-7 trial, which was the first clinical trial among moderate-to-severe CKD and T2DM displayed convincing protective effects on eGFR after treatment with GLP-1RAs [46]

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Over the years, this historical name revealed misleading because the preferred substrate that underlies the main physiological functions of ASCT2 is glutamine that is exchanged, in a Na + dependent manner, with other neutral amino acids such as serine or asparagine or threonine