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Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0183 433(2):310-323

Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0183 433(2):310-323

Name: Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0183 433(2):310-323
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SKU: 56614209862
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Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0183 433(2):310-323Furamidine, CAS No. 55368 40 6, is a potent, selective and cell permeable Protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9. 4 M. It has >10 fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 M respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell

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Description

433(2):310-323

In combination with an antimetabolite

for 21 days

Quizartinib inhibits MV4-11 and A375 cells with IC50 of 0

selective and cell permeable inhibitor of DNA methyltransferase

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