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For example, in the treatment of Alzheimers diseases (AD) and Parkinsons diseases (PD), GLP-1RAs have shown potential in slowing disease progression, while their anti-inflammatory properties offer new hope for conditions such as osteoarthritis (OA), rheumatoid arthritis (RA) and cardiovascular diseases

Understanding the evidence-based safety profile of tirzepatide is essential for informed decision-making

We review studies revealing the neuroprotective actions of GLP-1 analogues in pre-clinical models of AD and PD and promising results from recent clinical trials

Recently, an increase in BDNF synthesis has been demonstrated in a pentylenetetrazol (PTZ) kindling model of epilepsy, after chronic treatment with liraglutide in combination with antiepileptic drug, levetiracetam, which also exerted antidepressive effects, e.g

Persistent or severe symptoms may indicate the need for dose modification or additional supportive care, and can lead to dehydration and acute kidney injury if severe

While such a design provides a rigorous research platform, it may not fully reflect a real-world setting