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Direct Dosage: A single B12 injection often delivers a much higher dose directly into the system than a typical daily oral tablet, particularly when considering the limited absorption rate of the latter, contributing to their perceived and actual strength. However, for individuals with mild dietary deficiencies and no underlying absorption problems, high-dose oral B12 supplements (e.g., 1000-2000mcg daily) can sometimes overcome the need for intrinsic factor by allowing for a small amount of passive absorption, eventually raising levels, though this method is less predictable and slower than direct injection

We suggest that disulfidptosis might be a crucial novel pathological mechanism underlying CNS diseases

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10.3390/nu15143110 92 ZouW.FuZ.GuoX.YaoL.HongH.LuoY.et al (2023)

This evidence is further supported in animal models of depression (Tuon et al., 2021)