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Choline: A vital nutrient that supports liver function and assists in the transportation and metabolism of fats

L-Carnitine is generally considered safe when taken within recommended ranges

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If hot flashes are determined to be related to tirzepatide therapy and are intolerable despite conservative measures, your provider can discuss alternative treatment options or adjunctive therapies to manage symptoms while maintaining metabolic control

Avoid adding excessive brown sugar or honey, which can increase gastric fluid volume and discomfort

To account for potential dropout of up to 20%, a total of 24 subjects were planned for active treatment, and 12 subjects were planned for treatment with placebo (total for both placebo doses), leading to a total number of 36 subjects planned to start in the trial