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It does not capture changes in body composition, fat distribution, insulin sensitivity, or cardiometabolic risk over time

For individuals with high-stress jobs or those who need to be physically active during the day, this can be a significant deterrent

Cost should also be clear before treatment begins

doi: 10.1111/j.1467-789X.2004.00144.x 8 BlherM

Inter-individual microecological variations : gut microbiota compositional architecture exhibits 23-fold fluctuations across different timepoints within individual subjects and among different individuals (28)