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N-acetyl-cysteine (aka

Natural does not necessarily mean safe

Perer et al 31 confirmed the upregulation of stress-responsive genes ( HMOX1, HSPA6, CRYAB, XRCC2 ) and advanced glycation end products (AGEs) following DHA exposure

Additional toxic mechanisms include ionic mimicry and structural disruption, such as Pb interfering with neuronal signal transduction via calcium substitution, and Hg causing irreversible inactivation of key metabolic enzymes through binding to thiol groups (Jaishankar et al

SS attended scientific advisory committee meetings or received speaking fees from AstraZeneca, Atara, Boehringer Ingelheim, Bristol-Myers-Squibb, Covis, Novartis, Panalgo, Pfizer, CSL Behring, and Covispharma, all unrelated to this study

However, a recent 12-week multicenter study comparing the efficacy of GLA (320 mg/day) and ALA (600 mg/day) in participants with T2D and painful DPN found that after 12 weeks, both neuropathic symptoms and pain improved, and GLA was shown to be non-inferior (equally effective) to ALA in reducing pain intensity [115]