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The treatment with DHYZ reduced levels of ROS and MDA, thereby suppressing the expression of markers associated to ferroptosis, including Fe 2+ , SLC7A11, and GPX4 (Yang et al., 202b)

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BBB dysfunction BBB disruption and dysfunction in a pathological state prompts the leakage of blood constituents into the CNS, infiltration of various cells, abnormal transfer and clearance of ions and molecules responsible for reduction and dysregulation of cerebral blood flow (CBF), further causing various neurological deficits [66]