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\Sustained Efficacy: Once-weekly dosing supports long-term adherence and durable metabolic effects

The study design was 2 months of wash-out, 6 months of therapy, and 2 months of follow-up

Managing multi-drug resistant hypertension, particularly in the context of progressive Chronic Kidney Disease (CKD), demands innovation beyond traditional RAAS blockade

doi: 10.1038/s41586-022-05443-0 66 ZhangHLiuJZhouYQuMWangYGuoKet al

Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Tomeno, W., Imajo, K., Fujita, K., Yoneda, M., Kataoka, K., Taguri, M., Yamanaka, T., Seko, Y., Tanaka, S., Saito, S., Ono, M., Oeda, S., Eguchi, Y., Aoi, W., Sato, K., Itoh, Y., & Nakajima, A

Successful resolution of the primary indication that warranted revisions was 87.5%, the mean follow-up was 27.6 months, and one death occurred unrelated to the procedure after 2 months