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Per ADA guidelines, typical targets include fasting glucose of 80130 mg/dL and 12 hour postprandial values below 180 mg/dL for most adults

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Clinical Evidence for Combining Metformin With GLP-1 Therapy Multiple clinical trials have examined the safety and efficacy of metformin plus GLP-1 combination therapy

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14.3 Type 2 Diabetes - Adult Study D: TRESIBA Administered at the Same Time Each Day as an Add-on to Metformin with or without a DPP-4 Inhibitor in Insulin Nave Adult Patients The efficacy of TRESIBA was evaluated in a 52-week randomized, open-label, multicenter trial that enrolled 1030 insulin nave patients with type 2 diabetes mellitus inadequately controlled on one or more oral antidiabetic agents (OADs)