Alvespimycin Hydrochloride Catalog No.:M10918-2 2095244-42-9

2095244-42-9

In vitro screens of uptake and efflux transporters reveal renal organic anion transporters OAT1

but promotes Akt/PKB down-regulation and GSK3 activation

Its name is derived from the word "hesperidium"

Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM

Alvespimycin Hydrochloride Catalog No.:M10918-2 2095244-42-9Alvespimycin is an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Check for active clinical trials or