GW 5074 - CAS# 220904-83-6 Catalog No.:M10941-10 Yagishita S

Yagishita S

parainfluenza type 5 and rhinovirus type 14

3-dimethyl-7-oxo-4-thia-1-azabicyclo[3

PubMed Central PMCID: PMC4139156

CAL-130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity

GW 5074 - CAS# 220904-83-6 Catalog No.:M10941-10 Yagishita SGW5074 is a c Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis associated kinases when assayed in vitro. In contrast to its effect in vitro, treatment of neurons with GW5074 causes c Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf MEK ERK pathway. GW5074 prevents neurodegeneration and improves behavioral outcome in an animal model of Huntington's disease. GW5074 could have