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Ushakumari et al

Originally marketed for diabetes management, the drug is now used for weight loss in teens and adults

The label also warns about potential acute gallbladder disease and notes that tirzepatide may reduce the absorption of oral medications due to delayed gastric emptying, including oral contraceptives, which may require backup contraception for 4 weeks after initiation and after each dose increase

Analyses of treatment adherence showed directionally consistent results with analyses of treatment initiation for both incident SUDs and adverse outcomes among participants with pre-existing SUDs

Despite the lack of clinical symptoms, the R group also exhibited a differential metabolomics profile compared to HCs