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In addition to neural connections, the central clock system also synchronizes the circadian rhythms of the peripheral clock system through hormones or factors, such as arginine vasopressin (AVP) and tumor necrosis factor (TNF) ( FIGURE 1 The clock system mainly regulates metabolism in the following three ways

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This results in enhanced activities of SOD, CAT, and GSH-Px, reduced levels of ROS, MDA, and the oxidative DNA lesion marker 8-hydroxy-2-deoxyguanosine (8-OHdG) (Li et al., 2020)